Doç.Dr. MELİH ŞİMŞEK

1. Sucuoğlu İşleyen, Z., Muğlu, H., Alaca Topçu, Z., Beşiroğlu, M., Yasin, A. İ., Topçu, A., Şimşek, M., Şeker, M., & Türk, H. M. (2025). Factors Affecting the Survival of Metastatic Breast Cancer Patients Treated with CDK 4/6 Inhibitors. Medicina, 61(7), 1279. https://doi.org/10.3390/medicina61071279.

2. Ceylan, F., Aktürk Esen, S., Ünal, O. Ü., Aslan, F., Onur, İ. D., Ateş, Ö., Demirciler, E., Ünek, İ. T., Gülmez, A., Özen Engin, E., Taş, S., Gököz Doğu, G., Şimşek, M., Türk, H. M., İnal, A., Şahin, G., Yüksel, H. Ç., Tenekeci, A. K., Hızal, M., ... Uncu, D. (2025). Long-Term Outcomes of Patients Undergoing Conversion Surgery After Induction Chemotherapy: Turkish Oncology Group Study. Medicina, 61(5), 776. https://doi.org/10.3390/medicina61050776.

3. Kalkan NO, Ucar G, Esen SA, Bardakci M, Aydin SG, Celebi A, Simsek M, İleri S, Avci O, Akdağ G, Arici MO, Hendem E, Ak N, Yildirim O, Aykan NF, Uncu D, Sendur M, Olmez OF, Bilici A, Kostek O, Turk HM, Urakci Z, Dogan M, Karacin C, Bilen E, Ergun Y. Assessing the Efficacy and Safety of Shorter versus Extended Adjuvant Treatment Duration for Stage III Low-Risk Colon Cancer: A Comparative Analysis. Niger J Clin Pract. 2025 Feb 1;28(2):212-218. doi: 10.4103/njcp.njcp_848_23.

4. Sever, N., Şimşek, F., Onur, İ. D., Arvas, H., Guliyev, T., Şakalar, T., Çiçek, C. M., Orman, S., Çetin, E. B., Kayaş, K., Akbaş, S., Ağyol, Y., Güren, A. K., Erel, P., Kocaaslan, E., Paçacı, B., Tunç, M. A., Çelebi, A., Majidova, N., Durnali, M., Şimşek, M.,... Bayoğu, İ. V. (2025). Prognostic Factors in High Grade Osteosarcoma Patients Who Received Neoadjuvant Therapy and Subsequently Underwent Surgery: Data from the Turkish Oncology Group. Journal of Clinical Medicine, 14(6), 2024. https://doi.org/10.3390/jcm14062024.

5. Guliyev, T., Bakshaliyev, N., Özcan, G., Elagöz, Şahande, Şimşek, M., & Türk, H. M. (2025). A Rare Case of Left Ventricular Myocardial Metastasis of Patient Presenting with ST-Elevation Acute Coronary Syndrome : Myocardial Metastasis. Journal of European Internal Medicine Professionals, 3(1), 47–51. https://doi.org/10.5281/zenodo.14775991.

6. A. I. Yasin, M. Uluganyan, Z. S. Isleyen, A. Topcu, A. T. Shbair, M. Simsek, et al. Cardiac safety of ribociclib evaluated with 24-hour rhythm Holter electrocardiogram. Supportive Care in Cancer 2024 Vol. 32 Issue 8 Pages 492. DOI: 10.1007/s00520-024-08702-0.

7. Sucuoğlu İşleyen Z, Beşiroğlu M, Şimşek M, Yasin A, Topçu A, Akçakaya A, Seker M, Türk H. Pretreatment HALP Score Predicts Prognosis in Patients with Esophageal Cancer Treated with Chemoradiotherapy. EJMI. 2024; 8(2): 113-118. DOI: 10.14744/ejmi.2024.14917.

8. A. Topcu, A. I. Yasin, M. Besiroglu, Z. Sucuoglu Isleyen, Z. Alaca Topcu, M. Simsek, et al. Prevalence and co-incidence of geriatric syndromes according to the ECOG performance status in older cancer patients. Frontiers in Medicine 2024 Vol. Volume 11 – 2024. DOI: 10.3389/fmed.2024.1331246.

9. Simsek M, Besiroglu M, Akcakaya A, Topcu A, Yasin AI, Isleyen ZS, Seker M, Turk HM. Local interventions for colorectal cancer metastases to liver and lung. Ir J Med Sci. 2023 Dec;192(6):2635-2641. doi: 10.1007/s11845-023-03340-7.

10. Sucuoglu Isleyen Z, Besiroglu M, Yasin AI, Simsek M, Topcu A, Smith L, Akagunduz B, Turk HM, Soysal P. The risk of malnutrition and its clinical implications in older patients with cancer. Aging Clin Exp Res. 2023 Nov;35(11):2675-2683. doi: 10.1007/s40520-023-02538-0.

11. Çağlar Ünal, Abdulmunir Azizy, Senem Karabulut, Didem Taştekin, Arif Akyıldız, Serkan Yaşar, Şuayib Yalçın, Eyüp Çoban, Türkkan Evrensel, Ziya Kalkan, Zeynep Oruç, Sümeyra Derin, Zeynep Hande Turna, Doğan Bayram, Fahriye Tuğba Köş, Mehmet Ali Nihat Şendur, Nadiye Sever, Özlem Ercelep, Mustafa Seyyar, Umut Kefeli, Kazım Uygun, Melike Özçelik, Sercan Ön, Ulus Ali Şanlı, Kübra Canaslan, İlkay Tuba Ünek, Kadriye Bir Yücel, Nuriye Özdemir, Ozan Yazıcı, Halil Göksel Güzel, Derya Kıvrak Salim, Sema Sezgin Göksu, Ali Murat Tatlı, Çetin Ordu, Oğuzhan Selvi, Abdullah Sakin, Mehmet Emin Büyükbayram, Bengü Dursun, Yüksel Ürün, Hacı Arak, Gözde Ağdaş, Muzaffer Uğraklı, Engin Hendem, Melek Karakurt Eryılmaz, Burak Bilgin, Atakan Topçu, Melih Şimşek, Mahmut Büyükşimşek, Büşra Akay, Gülçin Şahingöz Erdal, Fatih Karataş, Özkan Alan, Melek Çağlayan, Fatma Akdağ Kahvecioğlu, Ayşe Demirci, Nail Paksoy, Bülent Çetin, Mahmut Gümüş, Naziye Ak, Yasemin Aydınalp, Semra Paydaş, Deniz Can Güven, Saadettin Kılıçkap, Sezer Sağlam, Efficacy of Capecitabine and Temozolomide Regimen in Neuroendocrine Tumors: Data From the Turkish Oncology Group, The Oncologist, Volume 28, Issue 10, October 2023, Pages 875–884, https://doi.org/10.1093/oncolo/oyad257.

12. Oz, E., Şimşek, A., Şimşek, M., Tuncer, N., Bayrak, M., Çadırcı, K., Brennan, C., Kumar, M., Proestos, C., Brennan, M., Elobeid, T., Zeng, M., Tomasevic, I., Ekiz, E. and Oz, F. (2023), A review on microbiota: relation with diseases and nutrients role. Int J Food Sci Technol, 58: 4100-4113. https://doi.org/10.1111/ijfs.16530.

13. Ünal Ç, Tunçer G, Çopur B, Pilanci KN, Okutur KS, Yararbaş K, Alan Ö, Sakin A, Simsek M, Ünal İÖ, Topçu A, Alaca Topçu Z, Duymaz T, Ordu Ç. Clinical and inflammation marker features of cancer patients with COVID-19: data of Istanbul, Turkey multicenter cancer patients (2020-2022). Curr Med Res Opin. 2023 Jul;39(7):987-996. doi: 10.1080/03007995.2023.2223917.

14. Topcu A, Yurtsever I, Isleyen ZS, Besiroglu M, Yasin AI, Topcu ZA, Shbair AT, Toluk O, Simsek M, Seker M, Turk HM. The correlation between skeletal muscle index and anxiety in patients with lung cancer on the first day of chemotherapy. Future Oncol. 2023 May;19(16):1139-1149. doi: 10.2217/fon-2022-1200.

15. Durna M, Topçu A, Yurtsever İ, Şimşek M, Aydın M, Şeker M. A Giant Metastatic Adrenal Cortical Carcinoma Case Presented with Rapid Progression. Acta Haematol Oncol Turc. ;56(2):185-189. doi: 10.5505/aot.2023.57984.

16. Baydas T, Coban G, Besiroglu M, Simsek M, Shbair AT, Topcu A, Yasin AI, Seker M, Turk HM. The prognostic value of tumor budding in gastric adenocarcinomas: A cross-sectional study. Int J Gastrointest Interv 2023;12:69-74. https://doi.org/10.18528/ijgii220012.

17. Aldemir, M. N., Turkeli, M., Simsek, M., Yildirim, N., Bilici, M., Dogan, C., ... Tekin, S. B.(2023). A Comparison of Weekly DCF versus Standard DCF as First-line Systemic Chemotherapy for Metastatic Gastric Cancer Patients. WEST INDIAN MEDICAL JOURNAL, no.1, 18-22. Doi: 10.7727/wimj.2016-536.

19. Simsek M, Yasin AI, Besiroglu M, Topcu A, Sucuoglu Isleyen Z, Seker M, Turk HM. The efficacy of BNT162b2 (Pfizer-BioNTech) and CoronaVac vaccines in patients with cancer. J Med Virol. 2022 Sep;94(9):4138-4143. doi: 10.1002/jmv.27835.

20. Karadeniz A, Bilici M, Şimşek M. The effect of demographic features on survival in patients with gastric cancer. ETD. 2022;61(2):166-72. https://doi.org/10.19161/etd.1125583.

21. Shbair AT, Yasin AI, Topçu A, Coban G, Uzunoglu GD, Şimşek M. Metastatic Breast Carcinoma Mimicking Urothelial Carcinoma. Int J Surg Pathol. 2022 Jun;30(4):466-469. doi: 10.1177/10668969211067923.

23. Şimşek M, Işık U, Gündüz O. Malign mezotelyomada kemoterapi uygulamaları. ETD. 2022;61(1):15-21. https://doi.org/10.19161/etd.1085601.

24. Yasin AI, Aydin SG, Sümbül B, Koral L, Şimşek M, Geredeli Ç, Öztürk A, Perkin P, Demirtaş D, Erdemoglu E, Hacıbekiroglu İ, Çakır E, Tanrıkulu E, Çoban E, Ozcelik M, Çelik S, Teker F, Aksoy A, Fırat ST, Tekin Ö, Kalkan Z, Türken O, Oven BB, Dane F, Bilici A, Isıkdogan A, Seker M, Türk HM, Gümüş M. Efficacy and safety profile of COVID-19 vaccine in cancer patients: a prospective, multicenter cohort study. Future Oncol. 2022 Mar;18(10):1235-1244. doi: 10.2217/fon-2021-1248.

25. Yilmaz TF, Gultekin MA, Turk HM, Besiroglu M, Cesme DH, Simsek M, Alkan A, Toprak H. Diagnostic performance of apparent diffusion coefficient values for the differentiation of intrahepatic cholangiocarcinoma from gastrointestinal adenocarcinoma liver metastases. Radiol Oncol. 2021 Dec 22;56(1):54-59. doi: 10.2478/raon-2021-0052.

26. Simsek M, Aliyev A, Baydas T, Besiroglu M, Demir T, Shbair AT, Seker M, Turk HM. Breast Cancer Patients with Brain Metastases: A Cross-Sectional Study. Breast J. 2022 Aug 19;2022:5763810. doi: 10.1155/2022/5763810.

27. Aldemir, M. N., Turkeli, M., Simsek, M., Cayir, K., Yildirim, N., Bilici, N. M., ... Ayan, A. K.(2022). mFOLFOX-based Chemotherapy Can Augment Survival in Advanced Gastric Cancer Patient with Disseminated Intravascular Coagulation. WEST INDIAN MEDICAL JOURNAL , vol.69, no.7, 520-522. Doi: 10.7727/wimj.2015.271.

28. Topcu A, Yasin AI, Shbair AT, Besiroglu M, Simsek M, Sucuoglu Z, Yurtsever I, Gucin Z, Seker M, Turk HM. A case report of fulminant hepatitis due to ribociclib with confirmed by liver biopsy in breast cancer. J Oncol Pharm Pract. 2022 Jan;28(1):242-246. doi: 10.1177/10781552211027931.

29. Turk HM, Adli M, Simsek M, Aliyev A, Besiroglu M. Successful retreatment with erlotinib after erlotinib-related interstitial lung disease. Tumori. 2021 Dec;107(6):NP84-NP86. doi: 10.1177/03008916211020097.

30. Yılmaz A, Şimşek M, Hannarici Z, Büyükbayram ME, Bilici M, Tekin SB. The importance of the glucose-to-lymphocyte ratio in patients with hepatocellular carcinoma treated with sorafenib. Future Oncol. 2021 Nov;17(33):4545-4559. doi: 10.2217/fon-2021-0457.

31. Bahçeci A, Paydaş S, Ak N, Ferhatoğlu F, Saip PM, Seydaoğlu G, Bilici M, Şimşek M, Tekin SB, Çalikuşu Z, Yavuz S, Şahin AB, Çubukçu E, Evrensel T, Değirmencioğlu S, Demiray AG, Yumuk PF, Alan Ö, Çikman Dİ, Demirelli FH, Köstek O, Gökyer A, Doğan M, Bal Ö, Çakar B, Gökmen E, Yamaç D, Korkmaz T, Aliyev A, Keskin Ö, Urvay S, Büyükşimşek M, Karadeniz C, Yildiz B, Çinkir HY, Demir H, Beypinar İ, Karaçin C, Eser K, Baykara M, Kiliçkap S, Okutur K, Bulut G, Alkan A, Arpaci E, Pilanci KN, Demir A, Işik D, Yildirim N. Efficacy and Safety of Trastuzumab Emtansine in Her2 Positive Metastatic Breast Cancer: Real-World Experience. Cancer Invest. 2021 Jul-Aug;39(6-7):473-481. doi: 10.1080/07357907.2021.1933011.

32. Aldemir MN, Simsek M, Kara AV, Ozcicek F, Mammadov R, Yazıcı GN, Sunar M, Coskun R, Gulaboglu M, Suleyman H. The effect of adenosine triphosphate on sunitinib-induced cardiac injury in rats. Hum Exp Toxicol. 2020 Aug;39(8):1046-1053. doi: 10.1177/0960327120909874.

33. ŞİMŞEK, M. (2020). Pituitary Gland Metastasis of Breast Cancer: A Rare Case Report and Review of the Literature. Journal of Oncological Sciences, 6(2), 127-130. https://doi.org/10.37047/jos.2020-75309.

34. Kiziltunc Ozmen H, Simsek M. Serum IL-23, E-selectin and sICAM levels in non-small cell lung cancer patients before and after radiotherapy. Journal of International Medical Research. 2020;48(5). doi:10.1177/0300060520923493.

35. Sımsek, M., Bılıcı, M., & Tekın, S. (2019). Single institution experience of thymoma and thymic carcinoma patients. Leukemia Research, 85, S25.

36. Isik, U., Erol, A., Cakmak, Y., Ozden, E., Kefeli, U., Cabuk, D., ... & Simsek, M. (2019). The effect of chemotherapy on survival applied in the last term of life in cancer patients. Leukemia Research, 85, S36.

37. Yıldırım, N., Aldemir, M. N., Şimşek, M., Bilici, M., & Tekin, S. B. (2019). Rare Breast Malignancies. Medical Journal of Bakirkoy, 15(3), 232-239. https://doi.org/10.4274/BTDMJB.galenos.2019.20180815080623.

38. Ulas Isik, Osman Kostek, Gokcen Demiray, Ahmet Dirican, Melih Simsek, Mahmut Büyüksimsek, Gokhan Ucar, Ulug Mutlu Gunaydin, Teoman Sakalar, Altay Aliyev, Atakan Demir, Serdar Turhal, Kezban Nur Pilanci, Umut Kefeli, Ali Gokyer, Semra Paydas, Dogan Uncu, Ilker Nihat Okten, Kazim Uygun, Devrim Cabuk. Real life data from Turkey regarding the impact of first-line sunitinib and pazopanib in metastatic renal cell cancer. Journal of Clinical Oncology 2019 37:15_suppl, e16075-e16075.

39. Yildirim N, Turkeli M, Akdemir MN, Simsek M, Tekin SB. Evaluation of 22 Primary Gastrointestinal Lymphoma Patients. Eurasian J Med. 2019 Feb;51(1):53-56. doi: 10.5152/eurasianjmed.2019.16071.

40. Bilici M, Şimşek M, Tekin SB. Mide kanserinde neo-adjuvan tedaviler. Türk HM, editör. Mide Kanserleri. 1. Baskı. Ankara: Türkiye Klinikleri; 2019. p.42-52.

41. Simsek M, Tekin SB, Bilici M. Immunological Agents Used in Cancer Treatment. Eurasian J Med. 2019 Feb;51(1):90-94. doi: 10.5152/eurasianjmed.2018.18194.

43. Ulas Isik, Serkan Gokcay, Melih Simsek, Semra Paydas, Gulgun Buyukdereli, Aysun Uguz,

Lymphocytic thyroiditis simulating thyroid cancer biochemically, radiologically and pathologically,

Journal of Oncological Sciences, Volume 4, Issue 2, 2018, Pages 114-115, ISSN 2452-3364.

https://doi.org/10.1016/j.jons.2018.04.003.

44. Bilici M, Şimşek M, Tekin SB. Meme Kanserinde İmmünoonkolojik Tedaviler. Tekin SB, editör. İmmünoonkoloji ve İmmünoonkolojik Tedaviler. 1. Baskı. Ankara: Türkiye Klinikleri; 2018. p.28-33.

45. Tekin SB, Şimşek M, Bilici M. Kanserin İmmünolojik Tedavisinde Kullanılan Ajanlar. Tekin SB, editör. İmmünoonkoloji ve İmmünoonkolojik Tedaviler.1. Baskı. Ankara: Türkiye Klinikleri; 2018. p.12-8.

46. Yildirim N, Simsek M, Aldemir MN, Bilici M, Tekin SB. Relationship between 18-FDG-PET/CT and Clinicopathological Features and Pathological Responses in Patients with Locally Advanced Breast Cancers. Eurasian J Med. 2019 Jun;51(2):154-159. doi: 10.5152/eurasianjmed.2018.18036.

47. Yildirim, N., Simsek, M., Turkeli, M., Bilici, M., & Ozmen, H. K. (2017). Early onset of radiation induced sarcoma: a case report and review of the literature. Acta Medica Mediterranea, 33(4), 565-568. DOI: 10.19193/0393-6384_2017_4_082.

48. Nilgün YILDIRIM, Melih ŞIMŞEK, Mehmet Naci ALDEMIR, Mehmet BILICI, Salim BAŞOL TEKIN. Gastrointestinal Stromal Tumors: A Single Center Experience. Turk J Oncol 2017;32(1):19-24. doi: 10.5505/tjo.2017.1523.

49. M.N. Aldemir, M. Turkeli, B. Hacioglu, A. Sakin, E. Yaman, E. Coban, D. Koca, M. Karaca, M. Simsek, A. Bahceci, E. Sen, T. Eren, B.ö Aliustaoglu, T. Sakalar, N.O. Kalkan, G. Aktas, M. Bilici, S. Turhal, M. Benekli, S.B. Tekin. Efficacy and tolerability of first-line chemotherapy in elderly patients (age ≥70 years) with metastatic gastric cancer: a multicenter study of the Anatolian Society of Medical Oncology (ASMO). Annals of Oncology 2016 Vol. 27 Pages vi220. DOI: 10.1093/annonc/mdw371.42.

50. TÜRKELİ, M., ALDEMİR, M. N., ŞİMŞEK, M., YILDIRIM, N., BİLİCİ, M., Cayir, K., ... TEKİN, S. B.(2016). EFFICACY AND TOLERABILITY OF CHEMOTHERAPY IN ELDERLY PATIENTS WITH METASTATIC GASTRIC CANCER. TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI , vol.19, no.1, 27-34.

51. Turkeli M, Simsek M, Aldemir MN, Yildirim N, Cankaya E, Erdemci B, Bilici M, Tekin SB, Arslan S, Korkut E. Are We Late in the Diagnosis of Malignities Occurring in Solid Organ Transplant Patients? 11 Years' Experience. Eurasian J Med. 2016 Feb;48(1):33-6. doi: 10.5152/eurasianjmed.2015.0087.

52. Simsek, M., Turkeli, M., Aldemir, M., Yildirim, N., TEKİN, S., & Bilici, M. (2016). Multicentric bone involvement and complete response to chemotherapy: A case report. Acta Medica Mediterranea, 32(1). Doi: 10.19193/0393-6384_2016_1_25.

53. Tarkun P, Atalay F, Atesoglu EB, Mehtap O, Simsek M, Terzi E, Geduk A, Balli F, Batman A, Baydemir C, Hacihanefioglu A. Treatment of patients with multiple myeloma over 65 yr: more tolerability or better response? Eur J Haematol. 2015 May;94(5):424-30. doi: 10.1111/ejh.12448.

54. Aldemir, M. N., Turkeli, M., Simsek, M., Yildirim, N., Bilen, Y., Yetimoglu, H., … Tekin, S. B. (2015, September 2). Prognostic Value of Baseline Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in Local and Advanced Gastric Cancer Patients. Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention. https://doi.org/10.7314/apjcp.2015.16.14.5933.

55. Turkeli M, Aldemir MN, Cayir K, Simsek M, Bilici M, Tekin SB, Yildirim N, Bilen N, Makas I. Efficacy and tolerability of weekly docetaxel, cisplatin, and 5-fluorouracil for locally advanced or metastatic gastric cancer patients with ECOG performance scores of 1 and 2. Asian Pac J Cancer Prev. 2015;16(3):985-9. doi: 10.7314/apjcp.2015.16.3.985.

56 . Erkan Dervisoglu, Melih Simsek, Ahmet Yilmaz. Antibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter? Clinics. Volume 66, Issue 9, 2011, Pages 1559-1562, ISSN 1807-5932. https://doi.org/10.1590/S1807-59322011000900009.

57. Simsek M, Tarkun P, Hacıhanefioğlu A. Retrospective analysis of patients diagnosed with multiple myeloma: A single center experience. Acta Haematol Oncol Turc. ;52(2):213-220. doi: 10.5505/aot.2019.24582.